Can Good Bacteria Kill Bad Bacteria? Berberine Dosing Recommendations. Berberine itself has many purported beneficial effects. Based on lab experiments, scientists believe berberine might lower LDL via: According to a large meta-analysis of clinical research, berberine supplements in combination with conventional therapy (amlodipin) reduces systolic blood pressure after 2 months [33]. This medicinal plant is used for its anti-pathogen and antioxidant properties. In one study, berberine (0.5 g, 3x/day for 3 months) performed similarly to metformin (a diabetes medication). Check out this post to learn which of its purported benefits are supported by science. USA.gov. Berberine can lower blood sugar levels, making it a great alternative to pharmaceutical... 3. Mol Aspects Med. Gut Microbes. One user said they didn’t see any changes in their health. Prevention and treatment information (HHS). 2017 May;70:72-84. doi: 10.1016/j.metabol.2017.02.003. No conclusions can be drawn from their findings. Total cholesterol and LDL decreased as well [5]. The following purported benefits are only supported by limited, low-quality clinical studies. Here, we examined the effect of berberine (BBR), a natural plant alkaloid, on intestinal bacteria using in vitro and in vivo models. There is insufficient evidence to support the use of berberine for any of the below-listed uses. Further research is needed to clarify these mixed findings [39, 40]. NIH Increases Heart Health. This is only about 1/200th of the levels that kill the bacteria shown in the accompanying table 13.2 (Bensky and Gamble 1986). That’s certainly the case here, as this is one of the best berberine supplements out there that comes in a vegetarian capsule. In another study, berberine reduced inflammation in the gut of mice with colitis and intestinal damage [67, 68]. 7 Proven Health Benefits of Berberine 1. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. Balances Blood Sugar. Front Nutr. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. We do not aim to diagnose, treat, cure or prevent any illness or disease. Berberine may help inhibit the growth of certain bacterial infections. In one study, it was as effective as metformin but with fewer side effects. A topical application of Berberine gelatin (5 mg/g) reduced pain and ulcer size in 84 people with canker sores[3]. Berberine could be an effective antimicrobial agent. In vitro, isolated mouse cecal bacteria were incubated with three doses of BBR (0.1, 1, and 10 mg/ml) for 4 hours in an anaerobic chamber. She loves communicating science and empowering people to achieve their optimal health. Berberine is a popular weight-loss supplement, but evidence is lacking to support its weight-reducing effects. Some doctors say that it isn’t necessary to take foods that are enhanced with probiotics, but if you do you can help your gut return to its healthy state. Berberine, however, can shut down that pump. Interactions between gut bacteria and bile in health and disease. Their reviews do not represent the opinions of SelfHacked. Scheme for determining the effects of BBR in vivo (A) and vitro (B). According to the proponents, it helps kill harmful bacteria. This site uses Akismet to reduce spam. Berberine creates new mitochondria by increasing SIRT1 and the NAD+/NADH ratio in rats [80]. In rats with ulcerative colitis, berberine reduced inflammation but also killed the commensal (good) bacteria in the gut. A rat study investigated the effects of berberine on depression and anxiety that often follow morphine addictions [75]. 2017 Aug;56:54-65. doi: 10.1016/j.mam.2017.06.002. Zhu C, Huang K, Bai Y, Feng X, Gong L, Wei C, Huang H, Zhang H. Poult Sci. Yes, even as the natural antibiotic is a gift for all forms of bacterial and yeast infections, it cannot differentiate between the good and the bad bacteria. Clinical studies have evaluated berberine (berberine HCl) at dosages ranging from 500mg to 1500mg per day for as long as six months in adults. 2021 Jan 11;21(1):24. doi: 10.1186/s12866-020-02020-1. People respond differently to diets and supplements because everyone has unique DNA. Both berberine and a multi-ingredient berberine supplement (berberine, policosanol, red yeast extract, folic acid, and astaxanthin) given daily for 4 weeks reduced total cholesterol, LDL, and triglycerides and increased HDL (40 subjects with moderate cholesterol issues) [24]. Supplementation also appeared to improve lipid  status (like LDL and total cholesterol) compared with metformin, the standard drug of choice [38, 39]. Join SelfHacked today and start the journey of improving your life. The benefits of berberine include being good for your gut and helping to control sugar cravings—to name just a couple. In clinical trials, berberine taken for 3 months prior to ovarian stimulation for in vitro fertilization (IVF) reduced fasting blood sugar, insulin resistance, total cholesterol, LDL cholesterol, triglycerides, testosterone levels, and waist-to-hip ratio [38, 39]. Although plausible, the overall evidence for its beneficial effects on cholesterol is weak. Scientists have raised numerous hypotheses about the ways in which berberine may help with diabetes on a cellular level, including all the following: However, larger trials are needed to verify the effectiveness of berberine in people with type 2 diabetes. People respond differently to diets and supplements because everyone has unique DNA. Selfhacked LLC does not provide medical advice, diagnosis, or treatment. Berberine might also help regulate how the body uses sugar in the blood. It also protected against infection-related liver damage in mice [66]. 2016 Nov;151(5):845-859. doi: 10.1053/j.gastro.2016.08.057. It also reduced inflammation of the liver and of the fat tissues in an animal model of non-alcoholic fatty liver disease [57]. 2021 Feb;100(2):1034-1048. doi: 10.1016/j.psj.2020.10.071. Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism. Large-scale clinical studies should be encouraged.

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